Phekolong ea melanoma e tsoetseng pele, katleho e bile mofuta o mocha oa immunotherapy, o sebelisoang hape Poland ho sehlopha se khethiloeng sa bakuli, litsebi li tsebisitsoe nakong ea seboka sa boralitaba Warsaw.
Hlooho ea tleliniki ea kankere ea lisele tse bonolo, masapo le melanoma Setsing sa Oncology se Warsaw, moprofesa. Piotr Rutkowski o boletse hore ho fihlela morao tjena, bakuli ba nang le melanoma e tsoetseng pele ba ne ba ka phela halofo ea selemo feela. Ka lebaka la immunotherapy e ncha, e notlollang PD-1 e amohelang lefu le ho kenya tšebetsong sesole sa 'mele ho loantša lisele tsa mofetše, halofo ea bakuli e phela likhoeli tse 24. Ba bang ba bona ba phela nako e teletsana.
Lithethefatsi tse thibelang PD-1 receptor li ngolisitsoe ho European Union, empa ha li e-so busetsoe Poland. Leha ho le joalo, li fumaneha linaheng tse ngata tsa Europe, ho kenyeletsoa. e Slovakia, Sweden, Czech Republic, Finland, Slovenia, Bulgaria, Ireland, Spain, Denmark, Luxembourg, Austria, Greece le Great Britain. Ka ntle ho EU, lithethefatsi tsena li boetse li buseletsoa United States, Canada, Israel le Switzerland.
"Re emetse ho buseletsoa ha litokisetso tsena, hobane ntle le bona ho thata ho bua ka phekolo ea morao-rao ea melanoma e tsoetseng pele ea metastatic, ho fa bakuli ba bang tšepo e kholo ea ho atolosa bophelo le ho ntlafatsa boleng ba eona" - a hatisa Prof. Rutkowski. Hangata meriana ena ha e bake litla-morao tse tebileng.
Ho fihlela joale, Setsi sa Tlhahlobo ea Theknoloji ea Bophelo le Litefiso se fane ka maikutlo a matle mabapi le puseletso ea lithethefatsi tse thibelang PD-1 tlas'a lenaneo la lithethefatsi hammoho le mekhoa e meng ea phekolo e amohelehang bakeng sa phekolo ea lefu lena.
Litokisetso tse notlollang moamoheli oa PD-1, leha ho le joalo, li sebelisoa naheng ea rona, ho fihlela joale ho sehlopha se khethiloeng sa bakuli. Prof. Rutkowski o re tabeng ea melanoma, ho fihlela joale e se e sebelisoa ho bakuli ba fetang 200, bao ba 100 ba bona ba ntseng ba phela. Ba ile ba tšoaroa e le karolo ea liteko tsa meriana kapa seo ho thoeng ke Lenaneo la Kalafo ea Ho Finyella Pele le tšehelitsoeng ka lichelete ke moetsi oa lithethefatsi.
“Lenaneo lena, le qalileng ka Hlakubele 2015, le ngolisitse bakuli ba 61 ba nang le metastatic melanoma e tsoetseng pele. Ho tsoa sehlopheng sena, bakuli ba 30 ba ntse ba phekoloa "- ho boletse Prof. Rutkowski.
Moeletsi oa naha lefapheng la bongaka ba oncology moprofesa. Maciej Krzakowski, hlooho ea tleliniki ea mofetše oa matšoafo Setsing sa Oncology se Warsaw, o boletse hore lithethefatsi tse notlollang li-receptor tsa PD-1 United States le European Union le tsona li amohetsoe bakeng sa kalafo ea mofetše oa matšoafo. Naheng ea Poland, hajoale li fumaneha feela e le karolo ea liteko tsa bongaka.
"Ho fihlela joale, lithethefatsi tsa mofuta ona li 'nile tsa sebelisoa feela e le phekolo e latelang (mohato oa III), ha mekhoa e meng ea phekolo e se e felile. Hona joale tšebeliso ea bona ea phekolo ea pele e nkoa e le "- ho boletse Prof. Krzakowski. Sena se fetola leano la kalafo bakeng sa mafu a kang melanoma e tsoetseng pele (mohato oa IV kapa o sa sebetseng, mohato oa III).
Prof. Krzakowski o hlalositse hore mefuta e mengata ea mofetše e qoba tlhaselo ea lisele tsa 'mele tsa ho itšireletsa mafung. Li thibela ketso ea PD-1 receptor holim'a lisele tsena (lymphocyte). Ba sebelisa mokhoa oo 'mele o o sebelisang ho thibela sesole sa' mele hore se se ke sa sebetsa ka mabifi (e leng se sireletsang mafu a autoimmune).
"Lithethefatsi tsa moloko o latelang li bula li-receptor tsa PD-1, li etsa hore sesole sa 'mele se tsebe hantle le ho loantša lisele tsa mofetše," ho boletse moeletsi oa naha.
Litsebi li ile tsa lumela nakong ea kopano le baqolotsi ba litaba hore ha ho na mokhoa oa ho tseba hore na ke mokuli ofe ea tla rua molemo ho mofuta ona oa immunotherapy. Tabeng ea melanoma, bakuli ba nang le maikutlo a phahameng a li-receptor tsa PD-1 hangata ba arabela hamolemo. Ka December 2015, e 'ngoe ea lithethefatsi tse joalo e ile ea amoheloa hape bakeng sa phekolo ea kankere ea liphio United States.
Prof. Krzakowski o boletse hore tharollo e ntle e tla ba ho tšehetsa mofuta ona oa phekolo ka tekanyetso ea mmuso ha e bonahala e sebetsa ho mokuli ea fanoeng. Ho phaella moo, ho boetse ho na le monyetla oa hore ka mor'a nako e itseng phekolo e joalo e ka khaotsa bonyane ho bakuli ba bang, ha sesole sa 'mele se ka khona ho laola tsoelo-pele ea lefu la neoplastic ka boeona.
Mokhatlo oa Amerika oa Clinical Oncology (ASCO) ka February 2016 o ile oa hlokomela immunotherapy (ho bula PD-1 receptor) e le katleho e kholo ka ho fetisisa ea oncology ka 2015. Sena se tlalehiloe tlalehong ea selemo ea 11 "Tlhaloso ea Kankere ea Kankere 2016". Immunotherapy e tla ba e 'ngoe ea lihlooho tsa mantlha tsa kopano ea selemo le selemo ea AZSCO, e tla qala Chicago qetellong ea Mots'eanong.