Lisosa tsa ho hloka thahasello le ho teneha ho lefu la Alzheimer lia senoloa

Matšoao ana, a bakoang ke ho shoa ha methapo ea kutlo karolong e ’ngoe ea boko, hangata a hlaha le pele mathata a ho hopola a hlaha.

Bafuputsi ba Indiana University School of Medicine (USA) ka lekhetlo la pele ba sibollotse mokhoa oa limolek'hule o bakang matšoao a neuropsychiatric ao hangata a etellang pele ho theoha ha bohlale ho lefu la Alzheimer's. Re bua ka tahlehelo ea tšusumetso, ho hloka thahasello, matšoenyeho, ho fetoha ha maikutlo ka tšohanyetso le ho teneha ho eketsehileng.

Bo-rasaense ba tsepamisitse maikutlo ho nucleus accumbens, sebaka sa boko se bapalang karolo ea bohlokoa tsamaisong ea moputso. E tsoa ho nucleus accumbens hore karabelo ea boitsebiso bo susumetsang e itšetlehile. 

Bafuputsi ba fumane hore bakuli ba Alzheimer ba na le li-receptor ka har'a li-nucleus accumbens tse lumellang calcium ho kena methapong. Ka tloaelo, ha hoa lokela ho ba le li-receptor tse joalo ka har'a li-nucleus accumbens. Khalsiamo e feteletseng e lebisa lefung la methapo ea kutlo le tahlehelo ea likhokahano tsa synaptic lipakeng tsa tsona, tse bakang matšoao a sebopeho sa neuropsychiatric.

Ho ipapisitsoe le sena, bo-rasaense ba fana ka maikutlo a hore thibelo e lebisitsoeng ea li-receptor tsa calcium nucleus accumbens e ka thibela kapa ea lieha ho qala ha lefu la Alzheimer's.

Mohloli: Molecular Psychiatry

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