Le fibrinogen ke protheine mali a bapalang karolo ho coagulation. O kenya letsoho thupelong ea tšelo ea mali hape e tsamaisa tšebetso ea liplatelete tsa mali le seleng ea ea likepe. Tlas'a ketso ea protheine e 'ngoe, the thrombin, e fetoha fibrin

E entsoe ke lisele tsa sebete. Boemo ba eona maling hangata bo fapana ho tloha ho 2 ho isa ho 4 g / l. Leha ho le joalo, synthesis ea sena protheine e ka 'na ea eketseha ka lebaka la khatello ea kelello, nakong ea bokhachane, kapa ka mor'a ho kenya meriana e itseng kapa hormone ea ho hōla. Ho eketseha ha boemo ba fibrinogen maling ho boetse ho bontša boemo ba ho ruruha.

Fibrinogen assay e bontšoa ho hlahloba bothata ba ho koala mali (mohlala ha ho tsoa mali ho sa hlalosoang kapa ” lefu la defibrination », E tsamaellanang le ho se tloaelehe ha coagulation).

Ho na le mathata a mararo a tsoalo maemong a fibrinogen:

• THElefu la afibrinogenemia, e leng ho ba sieo ho feletseng ha fibrinogen. Lefu lena le sa tloaelehang le baka mali a mangata a hlahang ho tloha tsoalong
• THEhypofibrinogenemia, e tsamaellanang le ho fokotseha ha boemo ba fibrinogen maling (sena ke sekoli ho secretion, hangata)
• La dysfibrinogenemia, e leng ho se tloaelehe ha protheine.

Teko ea mali ea fibrinogen le eona e ka ba molemo maemong a:

• lefu la ho ruruha
• ho hloleha ha sebete (ho lebisang ho fokotseha ha maemo a fibrinogen)
• ho shebella phello ea seo ho thoeng ke "fibrinolytic" phekolo, e reretsoeng ho qhaqha lesela la mali ha ho etsahala thrombosis.

Tekanyo ea fibrinogen e etsoa ka sampuli ea mali a venous (teko ea mali), laboratoring ea tlhahlobo ea bongaka. Tekanyo ke mokhoa o tloaelehileng, 'me hangata liphetho li fumanoa ka letsatsi.

Ngaka ke eona feela e ka hlalosang liphello tsa tlhahlobo.

Hangata, fibrinogen e feteletseng (hyperfibrinogenemia) e ka bonoa tabeng ea ho ruruha, ha ho e-na le mafu a itseng a tšoaetsanoang (pneumonia, joalo-joalo), haeba ho na le feberu ea ramatiki kapa mafu a autoimmune (lupus), ka mor'a lefu la myocardial, joalo-joalo.

Ka lehlakoreng le leng, hypofibrinogenemia (ho fokotseha ha boemo ba fibrinogen) e ka 'na ea bontša lefu la lefutso, ho se sebetse ho matla ha sebete (hepatitis, cirrhosis), mathata a coagulation (ho hasana ha intravascular coagulation kapa defibrination syndrome) kapa "fibrinolysis", mohlala ka lebaka la kankere.