Hyperlymphocytosis ke keketseho e sa tloaelehang ea palo ea li-lymphocyte maling. E ka ba e matla ha e kopana le tšoaetso ea kokoana-hloko kapa e sa foleng, haholo-holo ha e amahanngoa le malignant hemopathy. Hyperlymphocytosis e fumanoa nakong ea liteko tse fapaneng tsa mali. 'Me phekolo e itšetlehile ka sesosa.

Tlhaloso

Hyperlymphocytosis ke keketseho e sa tloaelehang ea palo ea lymphocyte maling ka tlwaelo e ka tlase ho 4000 lymphocyte ka cubic millimeter ho batho ba baholo.

Li-lymphocyte ke leukocyte (ka mantsoe a mang lisele tse tšoeu tsa mali) tse phethang karolo ea bohlokoa tsamaisong ea 'mele ea ho itšireletsa mafung. Ho na le mefuta e meraro ea lymphocyte:

• Li-lymphocyte tsa B: ha li kopana le antigen, li hlahisa li-antibodies ho ntho ena esele 'meleng
• T lymphocyte: Tse ling li senya li-antigen le lisele tse tšoaelitsoeng ka ho khomarela liseleng tsa tsona ho li enta ka li-enzyme tse chefo, tse ling li thusa B lymphocyte ho etsa masole a ’mele, ’me tse ling li hlahisa lintho tse thibelang karabelo ea ’mele ea ho itšireletsa mafung.
• Natural Killer lymphocyte: li na le ts'ebetso ea tlhaho ea cytotoxic e li lumellang ho senya lisele tse tšoaelitsoeng ke livaerase kapa lisele tsa mofetše.

Types

Hyperlymphocytosis e ka ba:

• A hlobaetsang ha a kopana le tšoaetso ea kokoana-hloko;
• E sa foleng (e tšoarellang ho feta likhoeli tse 2) haholo-holo ha e amahanngoa le lefu la malignant hemopathy;

Lisosa

Acute (kapa reactive) hyperlymphocytosis e ka bakoa ke:

• Tšoaetso ea kokoana-hloko (mumps, chickenpox kapa mononucleosis, lefu la sebete, rubella, tšoaetso ea HIV, lefu la Carl Smith);
• Matšoao a mang a baktheria, a kang lefuba kapa sefuba, a ka ba le phello e tšoanang;
• Ho noa meriana e itseng;
• Ente;
• Mathata a endocrine;
• mafu a Autoimmune;
• tsuba;
• Ho imeloa kelellong: hyperlymphocytosis e bonoa ho bakuli ba pepesehetseng liketsahalo tse fapa-fapaneng tse bohloko, tsa ho buuoa kapa tsa pelo, kapa nakong ea boikitlaetso bo boholo ba 'mele (ho beleha);
• Ho tlosa lesapo ka ho buoa.

Hyperlymphocytosis e sa foleng e ka bakoa ke:

• Leukemia, haholo-holo lymphoid leukemia;
• Lymphomas;
• Ho ruruha ho sa foleng, haholo-holo tsamaisong ea tšilo ea lijo (lefu la Crohn).

Diagnostic

Hyperlymphocytosis e fumanoa nakong ea liteko tse fapaneng tsa mali:

• Palo e felletseng ea mali: tlhahlobo ea bioloji e etsang hore ho khonehe ho lekanya likarolo tsa cellular tse potolohang maling (lisele tse tšoeu tsa mali, lisele tse khubelu tsa mali le liplatelete) le ho fumana karolo ea lisele tse tšoeu tsa mali tse fapaneng (haholo-holo li-lymphocyte);
• Ha palo ea mali e bontša ho eketseha ha palo ea li-lymphocyte, ngaka e hlahloba sampuli ea mali tlas'a microscope ho fumana hore na morphology ea lymphocyte ke efe. A heterogeneity e kholo ea morphology ea lymphocyte hangata e tšoaea mononucleosis syndrome, 'me ho ba teng ha lisele tse immature ke tšobotsi ea leukemias itseng kapa lymphomas;
• Qetellong, liteko tse eketsehileng tsa mali li ka boela tsa khetholla mofuta o itseng oa lymphocyte (T, B, NK) e ntseng e eketseha ho thusa ho tseba sesosa.

Batho ba amehang

Hyperlymphocytosis e ama bana ka bobeli bao ho bona e lulang e sebetsa le ea nakoana, hammoho le batho ba baholo bao e ka bang ea nakoana kapa e sa foleng (ka nako eo ke ba hlahang hampe ho 50% ea linyeoe).

Ka boeona, keketseho ea palo ea lymphocyte hangata ha e bake matšoao. Leha ho le joalo, ho batho ba nang le lymphoma le leukemia e itseng, hyperlymphocytosis e ka baka:

• Feberu ;
• Mofufutso oa bosiu;
• Ho theola boima ba 'mele.

Phekolo ea hyperlymphocytosis e itšetlehile ka sesosa sa eona, ho kenyelletsa:

• Phekolo ea matšoao ho mafu a mangata a vaerase a bakang hyperlymphocytosis e matla;
• Kalafo ea lithibela-mafu bakeng sa tšoaetso ea baktheria;
• Chemotherapy, kapa ka linako tse ling stem cell transplantation, ho phekola leukemia;
• Ho tlosoa ha sesosa (khatello ea maikutlo, ho tsuba)

Thibelo ea acute hyperlymphocytosis e kenyelletsa ho thibela tšoaetso ea kokoana-hloko le baktheria e ka bakang bothata bona:

• Ho entoa, haholo-holo khahlanong le mumps, rubella, lefuba kapa sefuba;
• Tšebeliso ea kamehla ea likhohlopo nakong ea thobalano ho itšireletsa khahlanong le HIV.

Ka lehlakoreng le leng, ha ho na mokhoa oa thibelo bakeng sa hyperlymphocytosis e sa foleng.