La 4 Phuptjane 2010 - Tšebeliso ea li-statins - lelapa la lithethefatsi ho theola k'holeseterole ea mali - e ka baka litla-morao tse 'maloa tse amang mahlo, sebete, liphio le mesifa.

Sena se bonts'oa ke bafuputsi ba Borithane ba ileng ba sekaseka lirekoto tsa bakuli ba fetang limilione tse 2, 16% ea bona ba neng ba e-na le li-statins kapa ba ne ba se ba ntse ba phekoloa.

Ho ea ka boitsebiso bo bokelitsoeng, bakeng sa basebelisi ba bang le ba bang ba 10, ho nka li-statins ka lilemo tse fetang 000 ho thibela linyeoe tse 5 tsa lefu la pelo, le 271 palo ea linyeoe tsa kankere ea 'mele.

Leha ho le joalo, e boetse e baka linyeoe tse eketsehileng tsa 307 tsa lefu la cataract, linyeoe tsa 74 tsa ho se sebetse ha sebete, linyeoe tse 39 tsa myopathy le linyeoe tse eketsehileng tsa 23 tsa maemo a itekanetseng kapa a matla a ho hlōleha ha renal, hape bakeng sa basebelisi ba bang le ba bang ba 10 ba lithethefatsi ho feta lilemo tse 000.

Litla-morao tsena li ile tsa hlaha hangata ho banna joaloka ho basali, ntle le myopathy - kapa ho senyeha ha mesifa - e ileng ea ama banna ba ka bang habeli ho feta basali.

'Me haeba litla-morao tsena li etsahetse ho pholletsa le lilemo tse 5 tseo bakuli ba ileng ba lateloa ho tsona, haholo-holo nakong ea 1^re selemo sa kalafo ba ne ba atisa ho fetisisa.

Lintlha tsena li sebetsa ho mefuta eohle ea li-statins tse sebelisitsoeng thutong, ke hore, simvastatin (e laetsoeng ho feta 70% ea barupeluoa), atorvastatin (22%), pravastatin (3,6%), rosuvastatin (1,9%) le fluvastatin (1,4). ,XNUMX%).

Leha ho le joalo, fluvastatin e bakile mathata a mangata a sebete ha e bapisoa le lihlopha tse ling tsa li-statins.

Ho ea ka bafuputsi, phuputso ena ke e 'ngoe ea tse' maloa ho lekanya boholo ba liphello tse kotsi tsa ho nka li-statins - boholo ba ho bapisa phello ea tsena ho fokotsa kotsi ea pelo le pelo ho placebo.

Hape, ba lumela hore mathata a bonoang ha aa lokela ho pata phokotso ea 24% ea linyeoe tsa lefu la pelo le methapo eo ho noa lithethefatsi ho faneng ka eona, ka har'a moralo oa thuto ena.

Ho mamela bakuli haholoanyane

Ka lebaka la litla-morao tse thathamisitsoeng phuputsong ena, bafuputsi ba khothalletsa hore lingaka li latele bakuli ba bona haufi-ufi ho lemoha kapele litla-morao tse ka 'nang tsa etsahala, ho fetola kapa ho emisa meriana ea bona, haeba ho hlokahala.

Hona hape ke maikutlo a setsebi sa lefu la pelo Paul Poirier, mookameli oa lenaneo la thibelo ea pelo le ts'ebetso ea ho tsosolosa ho Institut de cardiologie et de pneumologie de Québec.

"Phuputso ena e re fa lipalo tsa 'nete mabapi le ho hlaha ha litlamorao tse mpe,' me li tebile," o boletse joalo. Ho feta moo, tleliniking, ha mokuli ea phekoloang ka li-statins a e-na le bothata ba mesifa kapa mathata a sebete, meriana e emisoa. “

Kotsi e kholo ea ho tšoaroa ke lefu la cataract e makatsa Paul Poirier. "Boitsebiso bona bo bocha 'me ha bo bobebe kaha bo ama batho ba hōlileng ba seng ba ntse ba kula, hoo ho nang le kotsi ea ho eketsa bothata bo bong," o tsoela pele.

Ho latela ngaka ea lefu la pelo, liphetho hape ke temoso bakeng sa linaha tse hananang le mohopolo oa ho etsa hore li-statin li fumanehe ntle le lengolo la ngaka.

"Ho hlakile hore tšebeliso ea li-statins e hloka hore motho a behoe leihlo 'me a hloka hore bakuli ba tsebisoe ka ho lekaneng ka litla-morao tse ka bang teng," ho phaella moo ngaka ea lefu la pelo.

Empa ho feta moo, thuto ea UK e sebetsa e le khopotso ho lingaka tse phekolang bakuli ba tsona ka li-statins.

"Statin ke sethethefatsi se nang le likotsi 'me re tlameha ho latela bakuli haufi-ufi. Ka holim'a tsohle, re tlameha ho mamela le ho lumela mokuli ea tletlebang ka matšoao, le haeba tsena li sa thathamisoa libukeng tsa saense: mokuli ha se lipalo-palo kapa ka karolelano mme o tlameha ho phekoloa ka tsela e ikhethang ", ho phethela D.^r Sefate sa pere.

Martin LaSalle - PasseportSanté.net

1. Hippisley-Cox J, et al a, Litlamorao tse sa lebelloang tsa li-statins ho banna le basali Engelane le Wales: boithuto ba sehlopha sa batho ba sebelisang database ea QResearch, British Medical Journal, e hatisitsoeng Inthaneteng 20 May 2010,; 340: c2197.

2. Rosenberg H, Allard D, Prudence o tlama: Tšebeliso ea li-statins ho basali, Ketso ea ho sireletsa bophelo bo botle ba basali, June 2007.