Lijo tse letsoai, tseo ka tloaelo li leng kotsi bophelong, mefuteng ea lihlahala tsa murine li thibela ho hōla ha hlahala hobane li susumetsa tšebetso ea tsamaiso ea ’mele ea ho itšireletsa mafung, ho tlaleha makasine oa Frontiers in Immunology. Na lipatlisiso li tla sebelisoa nakong e tlang?
Ho noa letsoai le phahameng ke ntho e tsejoang e le kotsi bakeng sa khatello e phahameng ea mali le lefu la pelo. Liphuputso tsa morao tjena li boetse li bontšitse hore letsoai le lengata lijong le ka eketsa bohale ba lisele tsa 'mele tsa ho itšireletsa mafung, tse khothalletsang mafu a autoimmune.
Lijo tse robeli tse nang le letsoai le lengata ho feta kamoo u nahanang
Leha ho le joalo, le hoja tsamaiso ea ’mele ea ho itšireletsa mafung e potlakileng haholo e lematsa ho feta ho thusa ’mele o phetseng hantle, e ka fumana mosebetsi o molemo tabeng ea mofetše.
Joalokaha ho khothalelitsoe ke lithuto tsa laboratori mabapi le mefuta ea litoeba, tse entsoeng ke sehlopha sa machaba se etelletsoeng pele ke moprofesa. Markus Kleinewietfeld oa VIB (Flemish Institute of Biotechnology), ho noa letsoai le lengata ho thibela ho hōla ha hlahala. Phello e bonahala e bakoa ke phetoho ea ts'ebetso ea lisele tsa myeloid lineage suppression cell (MDSCs), tse bapalang karolo ea bohlokoa ntoeng khahlanong le mofetše. Li-MDSC li hatella ketso ea lisele tse ling tsa 'mele tsa ho itšireletsa mafung, empa sebakeng se nang le letsoai, liphello tsa tsona tse thibelang likokoana-hloko lia fokola 'me mefuta e meng ea lisele e hlasela hlahala ka matla. Phello e ts'oanang ea tikoloho ea letsoai ho MDSC e ile ea boela ea hlokomeloa ha lisele tsa hlahala tsa batho li hōlile.
Ho ea ka bangoli, lipatlisiso tse ling li ka ntlafatsa liphello tsa phekolo ea kankere ka tsela e bonolo le e theko e tlaase haholo. Empa pele, o hloka ho utloisisa ka botlalo phello ena le mekhoa e qaqileng ea limolek'hule. Hoa tsebahala hore ho noa letsoai le phahameng ho khothalletsa, ka mohlala, nts'etsopele ea kankere ea mala.