La 24 Pherekhong 2012 - Ha e ntse e sebelisoa ka bongata, lithethefatsi tse seng khahlanong le ho ruruha (li-NSAID) li bonahala li hlahisa kotsi ea 'nete bophelong bo botle. Har'a tse tsebahalang haholo ke aspirin, Advil®, Antadys®, Ibuprofen® kapa Voltarene®, lithethefatsi tseo hangata li laeloang.

Sehlopha sena sa lithethefatsi tse khahlanong le ho ruruha ho nahanoa hore se ka ba kotsi pelong le liphio. Ka sebele, li-NSAID li nkile boikarabello ba:

• Mathata a pelo

Ho kokobetsa bohloko, lithethefatsi tse seng li-steroidal tse khahlanong le ho ruruha li thibela tšebetso ea li-enzyme tse peli (= protheine e lumellang ts'ebetso ea biochemical) e bitsoang COX-1 le COX-2.

Ho thibela COX-2 ka li-NSAID ho thibela ho hoama ha mali le ho kopanya li-thromboxanes, lihormone tse nang le karolo ea vasoconstrictor, ka hona ho eketsa khatello ea mali le likotsi tsa pelo.

• Liso le ho tsoa mali ka tšilong ea lijo

COX-1 e lumella sebopeho sa li-prostaglandin, metabolite e hlahisoang ke spleen, liphio le pelo. Thibelo ea COX-1 ka li-anti-inflammatory anti-inflammatory e ntan'o e thibela ho sireletsa tšilo ea lijo, ka hona e ka baka seso sa peptic.

• Ho hloleha ha renal

Thibelo ena ea COX-1 e tla ts'ehetsa ho hloleha hoa renal ka ho fokotsa pompo ea liphio.

Ka kakaretso, ke batho ba tsofetseng ba amehileng haholo ke likotsi tsena, hobane tšebetso ea bona ea renal ea fokotseha, ke ho ikhanyetsa, ha re tseba hore lithethefatsi tse khahlano le ho ruruha li laetsoe hohle ho kokobetsa bohloko bo amanang le osteoarthritis.

Anaïs Lhôte - PasseportSanté.net

Source: Meriana ea hau, Philippe Moser