Ho fapana le lithethefatsi tse tloaelehileng tse batlang ho arola limolek'hule, limela li emela sehlopha sa lintho tse sebetsang ka synergy, 'me hantle-ntle keketso ena ea lintho e leng tšimolohong ea thepa ea bona e mengata. Artichoke (cynara scolymus) ke mohlala oa khale ka ho fetisisa o amanang le limolek'hule tse 4 (citric acid, malic, succinic et cynaropicrine) e leng, e nkiloeng ka thōko, ha e sebetse haholo, empa synergy ea bona e na le phello e matla ea pharmacological sebeteng le ts'ebetsong ea biliary.

Re ka ea ho fihlela re re limela li etselitsoe ho re folisa kaha limolek'hule tse ling tsa limela li na le kamano ea tlhaho le li-receptor tse liseleng tsa rona. Ka mohlala, morphine ho tloha poppy (Papaver somniferum) e tlama ho seo ho thoeng ke li-receptor tsa morphine tsa tsamaiso ea methapo e bohareng. Lintho tse sebetsang tsa valerian (valerian officinalis) le passionflower (passionflower incarnate) kopanya le li-receptor tsa boko bakeng sa benzodiazepines, limolek'hule tsa khutso. Ka kutloisiso ena, ha limela li sebelisoa hantle 'me li ikamahanya le litlhoko tsa rona, li emela meriana ea sebele.