Hypogammaglobulonemia ke ho fokotseha ha boemo ba gamma-globulins kapa li-immunoglobulins, lintho tse nang le karolo ea bohlokoa sesoleng sa 'mele. Bothata bona ba likokoana-hloko bo ka bakoa ke ho noa meriana e itseng kapa mafu a sa tšoaneng, ao a mang a 'ona a hlokang ho hlahlojoa kapele. 

Hypogammaglobulinemia e hlalosoa ke boemo ba gamma-globulin bo ka tlase ho 6 g/l ho protheine ea plasma ea electrophoresis (EPP). 

Li-gamma globulin, tseo hape li bitsoang li-immunoglobulins, ke lintho tse entsoeng ke lisele tsa mali. Li na le karolo ea bohlokoa haholo tšireletsong ea 'mele. Hypogammaglobumonemia e lebisa phokotsong e matla kapa e fokolang ea ts'ireletso ea 'mele ea ho itšireletsa mafung. Ke ntho e sa tloaelehang.

Tlhahlobo e lumellang ho etsa qeto ea li-gamma-globulins, har'a lintho tse ling, ke electrophoresis ea liprotheine tsa serum kapa liprotheine tsa plasma.E etsoa ha ho belaelloa mafu a itseng kapa ho latela liphello tse sa tloaelehang nakong ea litlhahlobo tsa pele. 

Tlhahlobo ena e laetsoe ha ho belaelloa hore motho o na le bofokoli ba ho itšireletsa mafung ha ho e-na le tšoaetso e pheta-phetoang, haholo-holo ea ENT le bronchopulmonary sphere kapa ho senyeha ha boemo bo akaretsang, haeba ho belaelloa hore ho na le myeloma e mengata ( matšoao: bohloko ba masapo, phokolo ea mali, mafu a khafetsa…). 

Teko ena e ka boela ea sebelisoa ho latela liphello tse sa tloaelehang tse bontšang ho eketseha kapa ho fokotseha ha protheine ea serum, protheine e phahameng ea moroto, k'halsiamo e phahameng ea mali, ho se tloaelehe ha palo ea lisele tse khubelu tsa mali kapa lisele tse tšoeu tsa mali.

Electrophoresis ea liprotheine tsa serum ke tlhahlobo e etsang hore ho khonehe ho lekanya li-gamma globulins. 

Teko ena e tloaelehileng ea baeloji (sampole ea mali, hangata e tsoang setsoe) e lumella mokhoa oa ho ata ha likarolo tse fapaneng tsa protheine ea serum (albumin, alpha1 le alpha2 globulins, beta1 le beta2 globulins, gamma globulin). 

Electrophoresis ea liprotheine tsa serum ke tlhahlobo e bonolo e etsang hore ho khonehe ho lemoha le ho kenya letsoho ho lekola li-pathologies tse ngata: li-syndromes tsa ho ruruha, mafu a mang a mofets'e, mathata a mmele kapa a phepo e nepahetseng.

E lebisa ho litlhahlobo tse ling tse hlokahalang (immunofixation le / kapa liteko tse khethehileng tsa protheine, tlhahlobo ea haematological, tlhahlobo ea renal kapa tšilo ea lijo).

Ho sibolloa ha hypogammaglobulonemia e ka ba ka lebaka la ho noa lithethefatsi (phekolo ea corticosteroid ea molomo, li-immunosuppressants, anti-epileptics, tumor chemotherapy, joalo-joalo) kapa mafu a fapaneng. 

Litlhahlobo tse ling li lumella tlhahlobo hore e etsoe ha sesosa sa lithethefatsi se sa amoheloe. 

Ho fumana li-pathologies e leng maemo a tšohanyetso a ho hlahloba (leseli la myeloma, lymphoma, leukemia e sa foleng ea myeloid), ho etsoa litlhahlobo tse tharo: ho batla lefu la hlahala (lymphadenopathy, hepato-splenomegaly), ho fumanoa ha protheine le palo ea mali.

Hang ha maemo ana a ts'ohanyetso a ts'oaetso a se a qheletsoe ka thoko lisosa tse ling tsa hypogammaglobulonemia li boleloa: nephrotic syndrome, exudative enteropathies. Lisosa tsa enteropathies exudative e ka ba boloetse bo sa foleng ba ho ruruha, lefu la celiac hammoho le lihlahala tse tiileng tsa ho senya lijo kapa li-lymphoid hemopathies tse itseng tse kang lymphoma kapa primary amyloidosis (LA, light chain amyloidosis of immunoglobulins).

Hangata, hypogammaglobulinemia e ka bakoa ke ho haella ha 'mele oa ho itšireletsa mafung.

Khaello e matla ea phepo e nepahetseng kapa Cushing's syndrome le eona e ka baka hypogammaglobulonemia.

Litlhahlobo tse ling li lumella tlhahlobo hore e etsoe (sekena sa thoraco-abdominal-pelvic scanner, palo ea mali, ts'ebetso ea ho ruruha, albuminemia, proteinuria ea lihora tse 24, boikemisetso ba boima ba immunoglobulins le immunofixation ea mali)

Kalafo e itšetlehile ka sesosa. 

E ka theha kalafo e thibelang ho batho ba nang le hypogammaglobulinemia: ente e khahlanong le pneumococcal le liente tse ling, lithibela-mafu prophylaxis, ho nkela sebaka ka polyvalent immunoglobulins.