Poleloana "collagenosis" e kopanya sehlopha sa mafu a autoimmune a khetholloang ke ts'enyo ea ho ruruha le ea sesole sa 'mele ho lithane tse hokahaneng, ts'ebetso e matla ea sesole sa 'mele, ho ata ha basali, ho kopana le li-antibodies tsa antinuclear le ho ata ha liso. Lithane tse hokahaneng li le teng ho pholletsa le 'mele, litho tsohle li na le boikarabello ba ho ameha ka mokhoa o amanang le ho feta kapa o fokolang, ka hona ho na le mefuta e mengata ea matšoao a ka bakoang ke collagenosis. Sepheo sa tsamaiso ea bona ke ho laola ts'ebetso ea maloetse le ho e fokotsa ho ea boemong bo tlaase ka ho fetisisa.

Collagenoses, eo hape e bitsoang connectivitis kapa mafu a systemic, a kopanya sehlopha sa mafu a sa foleng a sa foleng a autoimmune, a bakoang ke sebopeho se sa tloaelehang sa collagen liseleng tse ruileng ka har'a matrix a intercellular, e leng li-tissue tse hokahaneng.

Collagen ke protheine e ngata ka ho fetisisa 'meleng ea rona. E lumella litho tsa rona le 'mele ea rona hore e tsitse ntle le ho ba thata haholo, ha e ntse e tenyetseha ka ho lekaneng. E sirelelitsoe ke lisele tse kopanyang, collagen e sebelisana le palo e kholo ea limolek'hule tse ling ho etsa likhoele le ho hlahisa lisele tse nang le fiber tse nang le thepa e tšehetsang le e manganga.

E ka sehloohong ho basali, li-collagenase li khona ho fihla lithong tsohle (tsamaiso ea tšilo ea lijo, mesifa, manonyeletso, pelo, tsamaiso ea methapo). Ke ka lebaka lena lipontšo tsa eona li ngata joaloka palo ea litho tse amehileng. Ka linako tse ling boleng ba bophelo bo ameha haholo. Phello ea mafu ana e itšetlehile haholo-holo ka tšenyo ea litho tsa bohlokoa.

Collagenosis e tsebahalang haholo ke systemic lupus erythematosus (SLE). Collagenosis e boetse e kenyelletsa mafu a latelang:

• ramatiki;
• lefu la oculourethro-synovial (OUS);
• spondyloarthropathies (haholo-holo ankylosing spondylitis);
• lefu la Horton;
• Granulomatose ea Wegener;
• rhizomelic pseudo-polyarthritis;
• lefu la scleroderma;
• lefu le tsoakiloeng la systemic kapa Sharp syndrome;
• microangiopathie thrombotique;
• nodosa ea periarteritis;
• lefu la Gougerot-Sjögren;
• dermatomyositis;
• dermatopolymyositis;
• lefu la Behçet;
• sarcoïdose;
• histiocytosis;
• E ntse e le maladie;
• ho kula nako le nako;
• mafu a mangata le mafu a itseng a metabolism;
• lefu la sebete le sa foleng;
• mafu a lisele tse elastic;
• mafu a congenital kapa a fumanoeng a tlatsana le serum;
• lefu la scleroderma;
• lefu la Churg-Strauss;
• systemic vasculitis, joalo-joalo.

Li ntse li sa tsejoe. Mohlomong ho na le bothata ba tsamaiso ea 'mele ea ho itšireletsa mafung, joalokaha ho pakoa maling a bakuli, ho ba teng ha li-antibodies tse sa tloaelehang, tse bitsoang li-autoantibodies kapa li-anti-antinuclear antibodies, tse lebisitsoeng khahlanong le likarolo tsa lisele tsa' mele. Li-antigen tse ling tsa histocompatibility system (HLA) li fumaneha habonolo nakong ea mafu a itseng, kapa malapeng a mang a amehang khafetsa, e leng se fanang ka maikutlo a ho phahamisa karolo ea liphatsa tsa lefutso.

Lithane tse hokahantsoeng li le teng ho pholletsa le 'mele, litho tsohle li kanna tsa ameha ka tsela e amanang le ho feta, ka hona, matšoao a fapaneng a ka bakoang ke litlhaselo:

• hlalosa hantle;
• letlalo la letlalo;
• pelo;
• pulmonary;
• sebete;
• renal;
• methapo ea bohareng kapa ea peripheral;
• methapo ea mali;
• tshilong ya dijo.

Phetoho ea collagenosis hangata e nka mokhoa oa ho khutlela morao hangata o amanang le lefu la ho ruruha 'me o fetoha haholo ka bomong. Matšoao a sa tobang a bonahala ka maemo a fapaneng:

• feberu (feberu e bonolo);
• ho kokobetsa;
• mokhathala o sa foleng;
• tshebetso e fokotsehile;
• ho thatafalloa ho tsepamisa mohopolo;
• kutloelo-bohloko ho letsatsi le khanya;
• alopecia;
• kutlo ho serame;
• ho omella ha nko / molomo / botšehali;
• maqeba a letlalo;
• ho theola boima ba 'mele;
• bohloko bo kopantsoeng;
• ho ruruha ha mesifa (myalgia) le manonyeletso (arthralgia).

Ka linako tse ling bakuli ha ba na matšoao ntle le bohloko ba manonyeletso le mokhathala. Joale re bua ka li-connectivitis tse sa tšoaneng. Ka linako tse ling ho hlaha matšoao a mefuta e fapaneng ea mafu a amanang. Sena se bitsoa overlap syndrome.

Ka lebaka la monyetla oa ho senyeha ha litho tse ngata, ke habohlokoa hore lithuto tse fapaneng tsa bongaka li sebelisane haufi-ufi. Ho hlahlojoa ho thehiloe historing, ke hore histori ea motho ea kulang, le tlhahlobo ea hae ea litleleniki, ho batla matšoao a atisang ho kopana le 'ngoe kapa ho feta mafu ana.

Kaha li-collagenase li khetholloa ka palo e kholo ea tlhahiso ea li-anti-anuclear, tlhahlobo ea li-autoantibodies maling ke ntho ea bohlokoa ho theha tlhahlobo. Leha ho le joalo, boteng ba li-autoantibodies tsena hase kamehla bo amanang le collagenase. Ka linako tse ling ho boetse hoa hlokahala ho nka sampuli ea lisele kapa biopsy. Ho fetisetsoa ho setsebi ho buelloa ho netefatsa hore na ho fumanoa eng le ho qala phekolo e nepahetseng.

Sepheo sa ho laola collagenosis ke ho laola ts'ebetso ea mafu le ho e fokotsa ho ea boemong bo tlaase ka ho fetisisa. Kalafo e fetoloa ho latela mofuta oa collagenosis e fumanoeng le ho latela litho tse amehang. Corticosteroids (cortisone) le li-analgesics hangata li sebelisoa joalo ka mola oa pele oa ho emisa ho khutlela mokhoeng le ho khutsisa lipontšo tse bohloko. Ho eketsoa ha immunosuppressant, ka molomo kapa ka ente, ho ka 'na ha hlokahala. Tsamaiso e ka 'na ea boela ea kenyelletsa liente tsa mali tsa immunoglobulins kapa mekhoa ea ho hloekisa plasma (plasmapheresis) tikolohong ea sepetlele. Bakuli ba bang, ba kang ba nang le lupus, le bona ba ka rua molemo kalafong ea malaria.