Rett syndrome ke lefu lefu le sa tloaelehang la lefutso se sitisang kgolo le kgolo ya boko. E iponahatsa ho masea le masea, hoo e ka bang ka ho khetheha har'a banana ba.

Ngoana ea nang le lefu la Rett o bontša khōlo e tloaelehileng qalong ea bophelo. Matšoao a pele a hlaha pakeng tsa Likhoeli tse 6 le tse 18. Bana ba nang le lefu lena butle-butle ba na le mathata le tsamaiso, ho sebelisana 'me buisana le tse amang bokgoni ba bona ba ho bua, ho tsamaya le ho sebedisa matsoho a bona. Joale re bua ka polyhandicap.

Sehlopha se secha sa mathata a nts'etsopele ea pervasive development (PDD).

Leha ho le joalo, lefu la Rett ke lefu lefu la lefutso, ke karolo ea pervasive developmental disorders (PDD). Khatisong e latelang (e tlang 2013) ea Diagnostic and Statistical Manual of Mental Disorders (DSM-V), American Psychiatric Association (APA) e sisinya sehlopha se secha sa PDD. Mefuta e fapaneng ea autism e tla hlophisoa ka sehlopha se le seng se bitsoang "Autism Spectrum Disorders". Ka hona, lefu la Rett le tla nkoa e le lefu le sa tloaelehang la lefutso le arohaneng ka ho feletseng.