Ka 1962, rasaense oa Leamerika L. Hayflick o ile a fetola lefapha la baeloji ea lisele ka ho theha mohopolo oa li-telomere, tse tsejoang e le moeli oa Hayflick. Ho ea ka Hayflick, nako e telele (e ka khonehang) ea bophelo ba motho ke lilemo tse lekholo le mashome a mabeli - ena ke lilemo tseo lisele tse ngata haholo li seng li sa khone ho arohana, 'me ntho e phelang e shoa.
Mokhoa oo limatlafatsi li amang bolelele ba telomere ka ona ke ka lijo tse amang telomerase, enzyme e eketsang ho pheta-pheta ha telomeric ho isa lipheletsong tsa DNA.
Ho entsoe lithuto tse likete ho telomerase. Li tsebahala ka ho boloka botsitso ba genomic, ho thibela ts'ebetso e sa batleheng ea litsela tsa tšenyo ea DNA, le ho laola botsofali ba lisele.
Ka 1984, Elizabeth Blackburn, moprofesa oa biochemistry le biophysics Univesithing ea California e San Francisco, o ile a sibolla hore enzyme ea telomerase e khona ho lelefatsa li-telomere ka ho kopanya DNA ho tsoa ho RNA primer. Ka 2009, Blackburn, Carol Greider, le Jack Szostak ba ile ba fumana Moputso oa Nobel ho Physiology kapa Medicine bakeng sa ho sibolla hore na li-telomere le telomerase ea enzyme li sireletsa li-chromosome joang.
Ho ka etsahala hore tsebo ea li-telomere e tla re fa monyetla oa ho eketsa nako ea bophelo haholo. Ka tlhaho, bafuputsi ba ntse ba hlahisa meriana ea mofuta ona, empa ho na le bopaki bo bongata ba hore mokhoa o bonolo oa bophelo le phepo e nepahetseng le tsona lia sebetsa.
Sena se molemo, hobane li-telomere tse khutšoanyane ke ntho e kotsi - ha li lebise lefung feela, empa le ho mafu a mangata.
Kahoo, ho khutsufatsoa ha li-telomere ho amahanngoa le mafu, lenane la lona le fanoeng ka tlase. Liphuputso tsa liphoofolo li bontšitse hore mafu a mangata a ka felisoa ka ho tsosolosa tšebetso ea telomerase. Ena ke khanyetso e fokotsehileng ea sesole sa 'mele ho tšoaetso, le lefu la tsoekere la mofuta oa XNUMX, le tšenyo ea atherosclerotic, hammoho le mafu a neurodegenerative, testicular, splenic, intestinal atrophy.
Lipatlisiso tse ntseng li hōla li bontša hore limatlafatsi tse itseng li phetha karolo ea bohlokoa ho sireletsa bolelele ba telomere 'me li na le tšusumetso e kholo bophelong ba nako e telele, ho akarelletsa le tšepe, mafura a omega-3, le livithamine E le C, vithamine D3, zinki, vithamine B12.
Ka tlase ke tlhaloso ea tse ling tsa limatlafatsi tsena.
Astaxanthin
Astaxanthin e na le phello e ntle ea ho thibela ho ruruha 'me e sireletsa DNA ka katleho. Liphuputso li bontšitse hore e khona ho sireletsa DNA tšenyo e bakoang ke mahlaseli a gamma. Astaxanthin e na le litšobotsi tse ngata tse ikhethang tse etsang hore e be motsoako o ikhethang.
Ka mohlala, ke carotenoid e matla ka ho fetisisa ea oxidizing e khonang ho "hlatsoa" li-radicals tsa mahala: astaxanthin e sebetsa ka makhetlo a 65 ho feta vithamine C, ka makhetlo a 54 ho feta beta-carotene, le makhetlo a 14 ho feta vithamine E. Ke 550 linako tse sebetsang hantle ho feta vithamine E, le makhetlo a 11 ho feta beta-carotene ho fokotsa oksijene ea singlet.
Astaxanthin e tšela mokoallo oa mali-boko le mali-retinal (beta-carotene le carotenoid lycopene ha li khone ho etsa sena), e le hore boko, mahlo le tsamaiso ea methapo e bohareng li fumane tšireletso ea antioxidant le anti-inflammatory.
Thepa e 'ngoe e khethollang astaxanthin ho li-carotenoids tse ling ke hore e ke ke ea sebetsa e le prooxidant. Li-antioxidants tse ngata li sebetsa joalo ka li-pro-oxidants (ke hore, li qala ho hlahisa oxidize ho fapana le ho hanyetsa oxidation). Leha ho le joalo, astaxanthin, leha e le ka bongata, ha e sebetse joalo ka moemeli oa oxidizing.
Qetellong, e 'ngoe ea thepa ea bohlokoa ka ho fetisisa ea astaxanthin ke bokhoni ba eona bo ikhethang ba ho sireletsa sele eohle ho tloha timetsong: likarolo tsa eona tse qhibilihang ka metsing le tse qhibilihang ka mafura. Li-antioxidants tse ling li ama karolo e le 'ngoe feela kapa tse ling. Litšobotsi tse ikhethang tsa 'mele tsa Astaxanthin li e lumella ho lula ka har'a membrane ea sele, e sireletsa le bokahare ba sele.
Mohloli o babatsehang oa astaxanthin ke alga e nyenyane ea Haematococcus pluvialis, e hōlang sehlekehlekeng sa Sweden. Ntle le moo, astaxanthin e na le li-blueberries tsa khale tse ntle.
ubiquinol
Ubiquinol ke mofuta o fokolitsoeng oa ubiquinone. Ha e le hantle, ubiquinol ke ubiquinone e khomaretseng molek'hule ea hydrogen ho eona. E fumanoa ka broccoli, parsley le lilamunu.
Lijo tse halikiloeng / Probiotics
Ho hlakile hore lijo tse nang le haholo-holo lijo tse lokisitsoeng li khutsufatsa nako ea bophelo. Bafuputsi ba lumela hore melokong e tlang, liphetoho tse ngata tsa liphatsa tsa lefutso le mathata a sebetsang a lebisang mafung a khoneha - ka lebaka la hore moloko oa hona joale o ja ka mafolofolo lijo tsa maiketsetso le tse entsoeng.
Karolo e 'ngoe ea bothata ke hore lijo tse lokisitsoeng, tse jereng tsoekere le lik'hemik'hale, li atleha ho senya microflora ea mala. Microflora e ama tsamaiso ea 'mele ea ho itšireletsa mafung, e leng tšireletso ea tlhaho ea' mele. Lithibela-mafu, khatello ea maikutlo, li-sweeteners tsa maiketsetso, metsi a chlorinated le lintho tse ling tse ngata le tsona li fokotsa palo ea li-probiotics ka maleng, e leng se etsang hore 'mele o be le maloetse le ho tsofala pele ho nako. Ka mokhoa o nepahetseng, lijo li lokela ho kenyelletsa lijo tse lengoang ka tloaelo le tse lomositsoeng.
Vithamine K2
Vithamine ena e ka ba "vithamine D e 'ngoe" kaha lipatlisiso li bontša melemo e mengata ea bophelo bo botle ba vithamine. Batho ba bangata ba fumana tekanyo e lekaneng ea vithamine K2 (hobane e entsoe ke 'mele ka maleng a manyenyane) ho boloka mali a kopanya ka tekanyo e lekaneng, empa chelete ena ha ea lekana ho sireletsa' mele mathateng a tebileng a bophelo bo botle. Ka mohlala, liphuputso tse entsoeng lilemong tsa morao tjena li bontša hore vithamine K2 e ka ’na ea sireletsa ’mele khahlanong le kankere ea tšoelesa ea senya. Vithamine K2 e boetse e molemo bakeng sa bophelo bo botle ba pelo. E na le lebese, soya (ka bongata - ka natto).
magnesium
Magnesium e bapala karolo ea bohlokoa tlhahisong ea DNA, ho tsosolosoa ha eona le ho qaptjoa ha ribonucleic acid. Khaello ea nako e telele ea magnesium e fella ka ho khutsufatsa li-telomere 'meleng ea likhoto le moetlong oa lisele. Ho haella ha li-ion tsa magnesium ho ama bophelo bo botle ba liphatsa tsa lefutso hampe. Ho haella ha magnesium ho fokotsa matla a 'mele a ho lokisa DNA e senyehileng 'me ho baka ho se tloaelehe ho li-chromosome. Ka kakaretso, magnesium e ama bolelele ba telomere, kaha e amahanngoa le bophelo bo botle ba DNA le bokhoni ba eona ba ho itokisa, 'me e eketsa ho hanyetsa' mele khatellong ea oxidative le ho ruruha. E fumaneha ka spinach, asparagus, bran ea koro, linate le lipeo, linaoa, liapole tse tala le lettuce le pepere e monate.
Polyphenols
Polyphenols ke li-antioxidants tse matla tse ka liehisang ts'ebetso.